FitnessDose

Showing posts with label peptide. Show all posts
Showing posts with label peptide. Show all posts

Thursday, August 21, 2014

Insulin-Like Growth Factor Recombinant 3


IGF1 stands for insulin like growth factor. It mimics insulin in the human body and also at the same time makes the muscles more sensitive to insulin's effects. It is a growth factor and is the most potent one in the human body at that. IGF causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells. This was thought to only be possible during puberty. IGF is much more potent at this effect than growth hormone is, in fact almost all of the effects you see from growth hormone come from the increased amount of IGF that your liver produces when the GH is destroyed. So it would be very easy to say that IGF is a much more potent and cheaper alternative to GH use, although GH is more effective for fat loss than IGF due to some other effects that it causes such as metabolism increase and the ability to effectively use more insulin, T3, and anabolic steroids.

Another advantage that IGF has over GH is that it has much more of an affinity to attach to muscle cells instead of bone and organ cells. Growth hormone has been know to cause a lot of organ enlargement and bone elongation since it attaches to all types of receptor cells. IGF is much more likely to go where we want it, our muscle cells. IGF-1 attaches to myogenic stem cells which are only located in muscle and connective tissues. These myogenic stem cells are responsible for the production of myoblast cells which in turn are responsible for the buildup and repair of connective tissues (ligaments, tendons, cartilage, and joints to a certain extent).

So from this you can see that IGF-1 is great for increasing the strength of tendons and also for helping to heal existing injuries while at the same time helping to prevent them. IGF-1 is also responsible for increased protein synthesis and amino acid synthesis.

IGF does not have to be used along with anabolic steroids, GH, insulin, or thyroid hormones to be effective. It causes muscle growth on its own. In fact some people prefer to use it during their breaks from steroid cycles since IGF has no effect on natural test production. It could effectively be used along with HCG, clomid, and PGF2a for a hell of an off cycle stack which would allow your body to return to normal and still allow you to grow!! On its own IGF will give an increase of around 2 lbs. of new solid lean muscle tissue every two weeks, and is also is know for its ability to strip off body fat and GREATLY increase vascularity, body fat decreases of 5-8% over a 50 day cycle are not uncommon. But, of course you will be much happier with the results if you use the IGF along with anabolic steroids, testosterone, and insulin.

The use of steroids along with the IGF allow you to quickly mature and strengthen the new muscle tissue that the IGF has formed, and may also speed the process of hyperplasia. If you need any help setting up a great stack to
use along with the IGF just let me know and I can help you out. I speak with lots of top bodybuilders and guru's so I am very knowledgeable.

The dosage issue for IGF is where the most controversy lies. Dosages used by competitive athletes most commonly range anywhere between 60mcg/day to 100+mcg/day. The trick is finding the dosage that works best for YOU. For most the best results appear when you reach a dosage of 80mcg/day, while some do
receive good results from only 40mcg/day. I personally feel the best results begin to be noticed at a dosage of 100mcg/day. I personally am using 150mcg/day during my current cycle.

Also I should let you know that the form of IGF is the Long R3 analog. It has been chemically altered and has a longer half-life than regular IGF, which only lasts about 10 minutes in the human body once injected. The Long R3 IGF-1 has a half-life of 6-10 hours, so you will only need to inject once or twice per day. The best time to inject is after lifting and in the morning, so it would be best to use half the dosage in the morning and the other half after lifting. This will take maximal advantage of IGF's insulin
mimicking effects.

Tuesday, November 12, 2013

Peptide Hormones: Insulin

Insulin is produced in the beta cells of the pancreas from a larger peptide called preproinsulin. Endogenous insulin has a half-life of three to five minutes and the pancreas secretes about 40 to 50 units of insulin per day in normal adults. Insulin secretion is stimulated in response to feeding with glucose being the strongest stimulator. Insulin binds to a cell surface receptor resulting in increased glucose and amino acid transport through the cell membrane and glycogen and lipid synthesis and storage. This is accomplished through the increased movement of Glut4 molecules to the surface of the cell membrane. Glut4 is the main transporter of glucose across cell membranes into cells. Insulin also binds to the type 1 IGF receptor which results in growth stimulating effects in muscle cells.

Insulin is the main “storage” hormone and is very anabolic as well as anti-catabolic. In addition to increasing glycogen and lipid synthesis and storage, insulin also promotes protein synthesis in skeletal muscle and promotes glycogen storage by increasing glucose transport in skeletal muscle cells.

Insulin and insulin syringes are available in many states without a prescription making insulin a more available anabolic hormone than AAS. That being said, the dangers of insulin are immediate and potentially deadly. Insulin can produce in a state of severe hypoglycemia that can result in coma or death with a matter of minutes. In addition, insulin resistance will occur over time in healthy individuals using insulin. While this risk is down-played by users and on boards discussing insulin, it should be considered a very real risk. Though insulin is highly anabolic in skeletal muscle, it is also very anabolic in adipose tissue. This can result in increases in body fat, especially when used in high doses on its own. Often insulin is combined with growth hormone to take advantage of growth hormone’s fat burning ability and to combat the decrease in insulin sensitivity with GH. IGF-1 is sometimes combined with insulin (and GH) but this increases the risk of hypoglycemia.