Active Half-life of Steroids and Esters

An important thought once designing a steroid cycle, specially the temporal arrangement of dosing to be administered, is that the active half-life of the drug being used. Steroids

The half-life is also outlined because the time the amount is 1/2 the beginning level of a given compound; at time 2t, the amount may be a quarter of the beginning level, and at time 3t, the amount is AN eighth of the beginning level, and so on.

This info is important within the temporal arrangement of the dosing once making an attempt to attain a a lot of stable blood concentration, that ends up in larger overall results and maintenance of gains. Some fluctuations of concentration levels ar acceptable, and also are principally inevitable, however ought to be unbroken to a minimum.

This article covers the half-life’s of the foremost normally used steroids, esters and adjutant compounds.

Oral steroids

Drug	Active half-life
Anadrol / Anapolon (oxymetholone)	8 to 9 hours
Anavar (oxandrolone)	9 hours
Dianabol (methandrostenolone, methandienone)	4.5 to 6 hours
Methyltestosterone	4 days
Winstrol (stanozolol) (tablets or depot taken orally)	9 hours

Steroid esters

The half-life applies to the ester regardless of hormone attached, for example trenbolone enanthate and primobolan (methenolone enanthate) will act very similarly to testosterone enanthate in terms of release rate.

Drug	Active half-life
Suspension	within 1 hour
Acetate	1 day
Propionate	1 day
Phenylpropionate	1-2 days
Butyrate	2-3 days
Valerate	3 days
Hexanoate	3 days
Caproate	4-5 days
Isocaproate	4-5 days
Heptanoate	5-6 days
Enanthate	5-6 days
Octanoate	6-7 days
Cypionate	6-7 days
Nonanoate	7 days
Decanoate	7-8 days
Undeclenate	8-9 days
Undecanoate	Approx 20 days

Ancillaries

Drug	Active half-life
Arimidex	3 days
Clenbuterol	1.5 days
Clomid	5 days
Cytadren	6 hours
Ephedrine	6 hours
T3	10 hours

Nolvadex and Clomid (estrogen receptor antagonists)

Estrogen receptor antagonists, more simply referred to as anti-estrogens (though this term is often loosely applied to all estrogen maintenance drugs), are drugs that block estrogens from exerting activity in the body. This is actualized by the ability of a particular substance to bind to a segment of the estrogen receptor, yet not activate it. This in turn prevents other estrogens from binding and activating the same receptor site. In a clinical setting an estrogen antagonist, most prominently the drug tamoxifen citrate (sold under the brand name Nolvadex) is typically used as the first line of defense during advanced breast cancer therapy. Its use can efficiently deprive estrogen responsive cancer cells of necessary hormone, allowing a high rate of response in patients with such forms of cancer.
Stronger agents such as aromatase inhibitors (discussed below) are usually a second choice, substituted when conventional antiestrogen therapy fails to elicit the desired response.
A drug like tamoxifen is preferred over other agents as the first course of breast cancer treatment for a number of reasons, most due to the fact that that it is both extremely effective yet does not inhibit the actual formation of estrogen in the body. Among other things, this may allow Nolvadex therapy to be somewhat more comfortable for the patient. Although many women (particularly pre-menopausal) seem to suffer menopausal-like side effects with virtually all estrogen maintenance drugs, estrogen antagonists are often somewhat more tolerable than agents that block the synthesis of estrogen. In fact the activity of tamoxifen is itself variable, such that in certain target tissues it may actually act as an agonist (activator) of the estrogen receptor. It therefore does not completely diminish the biological activity of estrogens, though it does considerably reduce it nonetheless.
It is also well understood in medicine today that estrogens play a supportive role in the cardiovascular system. For example, studies show that a rise in the estrogen level (as in post-menopausal estrogen replacement therapy) is typically linked with a reduction in LDL (bad) cholesterol, and a rise in HDL (good) cholesterol. The ability of tamoxifen to act as an estrogen agonist in the liver likewise gives it what may be its most welcome property, namely that it exhibits an estrogenic, rather than antiestrogenic, effect on blood lipid (cholesterol) values. As a 1998 study by the Department of Clinical Oncology in the Netherlands Cancer Institute shows, during long-term treatment with tamoxifen (6 months) a lowered LDL cholesterol level, and significantly elevated HDL cholesterol level and HDL-C/total-cholesterol ratio may result. This trend should reduce an important risk factor for heart disease, obviously a welcome effect during treatment.
For the steroid-using athlete already faced with negative alterations in lipid profiles, such an effect could obviously an important consideration.
Clomid (clomiphene citrate) is very similar in structure to Nolvadex, both drugs being classified as triphenylethylene compounds and used clinically for similar purposes (breast cancer as well as female infertility treatment). As well as we see with Nolvadex, Clomid is a partial agonist/antagonist of the estrogen receptor depending on the target tissue in question. Although athletes most commonly think of Clomid as a testosterone-stimulating drug only (another effect of antiestrogenic compounds), to be used at the conclusion of steroid treatment, its activity in the human body is not at all dissimilar to Nolvadex. It should likewise be thought of not as a drug with its own niche of use, but instead as another efficient remedy for gynecomastia similar to Nolvadex (with the related ability to support the release of testosterone). It could clearly replace Nolvadex as a preventative measure against gynecomastia during cycles with aromatizable steroids without noticeably altering the level of effect received, just as Nolvadex can be used effectively to increase the synthesis of testosterone in the body at the conclusion of steroid use.

Protein Supplementation

Protein-powder is a very popular supplement, and is available at most local drug and health food stores. Before proteins can be used for muscle hypertrophy in the body, they must be broken down to amino acids in the liver. In the liver, they can be resynthesized into muscle proteins, and transported to the muscles for hypertrophy.
Obviously, if the proper stimulus is given, the more amino acids responsible for muscle growth that are present in the body, the more muscle hypertrophy will occur. Simply put, the more protein in the body, the more muscle hypertrophy will occur.
Studies show that ingestion of protein with carbohydrate increases insulin and/or growth hormone level, thus assisting the process of muscle growth. The intake of protein and carbohydrate before exercise boost the efficiency of the workout and lessens recovery time, allowing the athlete to endure more vigorous training sessions. As much as 1.3 to 1.8 g of protein for every Kg of body mass, or 2.2 g at high altitudes, is recommended for weight trainers per day. It is shown that 20 calories per pound of body mass is required to sustain muscle mass, and 25 to 30 calories per pound to actually build muscle mass. Thirteen to seventeen percent of those calories should come from proteins, with twelve to sixteen percent coming from fats, and the rest obtained from carbohydrates.
Tests show that taking protein supplements along with creatine monohydrate works better than just taking protein supplements alone. The positive effects include leaner tissue mass, and increase in bench press power. Another independent study shows how a combination of protein and creatine helps boost muscle GLUT-4 (glucose transport proteins) matter and increases glucose tolerance in the athlete. Human subjects’ right leg was immobilized for the time period of two weeks, and then resistance exercises were put in place for six weeks. GLUT-4 content was decreased in creatine-taking subjects, creatine and protein-taking subjects, and placebo-taking subjects during the 2 weeks of immobilization. When the resistance exercise program was introduced, the GLUT-4 content in creatine-taking subjects were up by 24%, creatine and protein-taking subjects’ GLUT-4 content were increased by 33%, while placebo-taking subjects’ GLUT- content remained constant. Muscle glycogen content in both creaine-taking and creatine and protein-taking subjects, but not placebo-taking subjects.

Anavar Oxandrolone for a Strong Increase in Strength

Anavar 20 (Oxandrolone) is an oral steroid which contains 20 mg of the hormone Oxandrolone. Anavar (Oxandrolone) is a mild drug, when taken in doses less than 40 mg per day did not give any side effects, because drug originally designed for women and children. This is one of the few steroids which does not cause premature delay physical development in adolescents, because it does not contribute to the closure of epofiznyh compounds, and the drug is used primarily at teenagers to promote growth of the body and women - in osteoporosis. The drug causes a very weak phenomenon of masculinization. This quality makes it a favorite tool for athletes, because at a dose of 10-15 mg per day they have rarely seen the outward manifestations of masculinity.

Anavar 20 (Oxandrolone) promotes a strong increase in strength. This is due to the fact that excited the synthesis of creatine phosphate in muscle cells and thus does not accumulate fluid. Anavar (Oxandrolone) gives them the opportunity to become stronger, not adding to their own weight. Although Oxandrolone itself and does not contribute to significant growth of muscles, but markedly enhances the effect of many steroids in the body, especially combined with Deca-Durabolin, methane and various versions of testosterone, as arises when taking Oxandrolone strength gains while taking Deca-Durabolin, methane or testosterone that accumulate fluid and contribute to a strong increase in muscle, the result is more muscle mass.

Oxandrolone does not aromatize nor at any dose. With Oxandrolone muscle never gets watery form, which makes to consider the drug a good way to prepare for competition. In combination with diet Oxandrolone helps to make the muscles firm and toned. Though he does not destroy the fat, it still plays an indirect role in this process, because the chemical suppresses appetite in many athletes. Oxandrolone may cause something like a feeling of heaviness in the stomach, causing some athletes nausea and vomiting if tablets taken with meals. Those who train for competition or increase interest in quality muscles should combine Oxandrolone with steroids as Winstrol, Parabolan, Primobolan and testosterone propionate.

Even in very high doses (more than 40 mg daily) Oxandrolone has no effect on the production of testosterone. Oxandrolone does not suppress the production of hormones in the body, as he does not have a negative effect on the arc of the hypothalamic-pituitary-testes, ie when receiving the testes do not signal the hypothalamus of the need to reduce emissions and the complete cessation of hormone releasing hormone and luteinizing hormone, as is the case with most taking anabolic steroids. This special position of Oxandrolone can be easily explained by the fact that its substance does not aromatize into estrogen. With regard to dosage of Oxandrolone, it is 20-30 mg per day for men and 15-20 mg for women, bring good results. In the first two or three weeks the daily dose of 0.25mg per kg of the drug proved itself in practice, the tablets are usually taken 3 times a day (since the half-life of 8 hours) after meals, and thus achieved optimal resorption (optimal intake) drug. Those who do encounter while taking the drug gastro-intestinal upset, do the right, taking a pill an hour - two after eating.

Oxandrolone is no toxic and has virtually no side effects, it shall take a long period of time, or during the period between cycles will help maintain the results achieved. But do not use it for several months without a break since it like almost all oral steroids, alkylated by 17-alpha and has a strain on the liver.
Women should not take the medication in a dose more than 6 tablets per day, as otherwise may arise due to side effects of androgen in the form of acne, breaking votes, decreased deep voice, clitoral blood pressure and enhanced precipitation bands.

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