Properties of Deca Durabolin
Nandrolone is a stronger anabolic steroid than Testosterone, but not by a great deal. Nandrolone possesses an anabolic rating of 125, while Testosterone holds an anabolic rating of 100. Nandrolone’s favorability lies in its very low androgenic rating of 37, while Testosterone holds an androgenic rating of 100 – quite significant compared to the androgenic strength of Nandrolone. The lower androgenic activity of Nandrolone is due in large part to the fact that Nandrolone converts into Dihydronandrolone, which is known to be a much less potent androgen. Nandrolone possesses very low Estrogenic activity and binds very poorly with the aromatase enzyme, which is the enzyme responsible for the conversion of androgens into Estrogen. It is estimated that only approximately 20% of Nandrolone is converted into Estrogen in comparison with Testosterone’s conversion rates[2]. This is due in very large part to the fact that Nandrolone is a Progestin (as are all 19-nor compounds)[3]. The other major factor in this is the fact that Nandrolone can undergo Estrogen conversion in the liver, but other locations where there is a high rate of Estrogen conversion (such as fat tissue), Nandrolone is quite resistant[4]. Progestins are very resistant to Estrogen conversion, but the fact that Nandrolone is a Progestin presents various issues itself.
Nandrolone lacks the 19th carbon that Testosterone possesses, which makes it a Progestin and it has been demonstrated that 19-nor anabolic steroids tend to exhibit binding affinity for the Progesterone receptors in the body[5]. As mentioned above, this presents some issues that are not commonly seen with other anabolic steroids that are not Progestins. Nandrolone is considered to possess moderate Progestogenic activity. Progestogenic side effects are almost identical to Estrogenic side effects, and they include: severe endogenous Testosterone production shutdown/suppression, gynecomastia, and water retention. It has been discovered that the activity of Progestins is closely correlated with the activity of Estrogen in the body. There also exist some side effects associated with Progestins that are not seen in other anabolic steroids.
19-nors being Progestogenic compounds are known to increase a hormone in the body known as Prolactin. Prolactin levels above normal in men often results in side effects such as lactating nipples, erectile dysfunction, anorgasmia (inability to achieve orgasm) and endogenous Testosterone production suppression/shutdown. An interesting point to learn is the fact that Progesterone itself is known to inhibit Prolactin production, and that 19-nors such as Nandrolone and Trenbolone being classified as Progestins should serve to actually suppress Prolactin levels. However, this is not the case as Nandrolone and Trenbolone are not Progesterone themselves – they are anabolic steroids that exhibit Progestogenic activity due to their chemical modifications and it is therefore very possible for these hormones to exhibit activity that is contrary to the activity of a similar hormone or parent hormone. It has been found that Nandrolone and Trenbolone can and do in fact increase Prolactin levels in the body.
Prolactin increases can be controlled either with the use of Prolactin antagonist drugs (such as Cabergoline or Pramipexole), however, prevention of rising Estrogen levels are also an effective method. For one thing, it is strongly speculated that the Estrogen in fact serves as a co-binding factor in the Prolactin receptor expression (PRLR). This can increase an individual’s sensitivity to Prolactin even if Prolactin levels themselves are not high in the body. This is a very sound theory when it is understood that the Estrogen receptor is a causative factor in Prolactin issues. Therefore, controlling Estrogen levels should control the effects of Prolactin. This is the number one reason why the side effects associated with 19-nor compounds (such as Nandrolone and Trenbolone) are frequently reported to be far more pronounced and with greater severity when they are used in a high Estrogen environment (whether it is from stacking Nandrolone or Trenbolone with high aromatizable doses of an aromatizable compound, such as Testosterone or otherwise).
It is because of the Progestogenic nature of Nandrolone that it is known to produce severe endogenous natural Testosterone production suppression and shutdown. Therefore, it is recommended that at all times whenever using Deca-Durabolin in a cycle that Testosterone be utilized with it in order to maintain normal physiological function of Testosterone in an environment in which natural Testosterone production has halted or been severely lowered.
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