FitnessDose

Thursday, April 16, 2015

Clomid in Post Cycle Therapy (PCT)

Clomid is a generic name for Clomiphene Citrate and is a synthetic oestrogen. It is prescribed medically to aid ovulation in low fertility females.

When we use anabolic steroids, the level of androgens in the body rises causing the androgen receptors to become more highly activated, and through the HPTA, a signal tells our testes to stop producing testosterone. During a cycle the body has far higher than normal levels of androgens and, as long as this level is high enough, Clomid will not help to keep natural testosterone production up. It will be almost all but completely shut off, in theory.

Some heavy androgen users, however, do advocate a small burst of Clomid mid-cycle, though it must be hard for them to say if it really of any benefit, due to the amount of gear they are using. Therefore, the only purpose of Clomid during a cycle is as an anti-estrogen.

When To Take Clomid
The correct time to commence Clomid depends on the type and cycle of steroids you have been using. Different steroids have different half-lifes (indicates the time a substance diminishes in blood), and Clomid administration should be taken accordingly.

As we have seen above, Clomid taken when androgen levels in our blood are still high will be a waste. It is crucial to wait for androgen levels to fall before implementing our Clomid therapy. However, if taken too late we could possibly lose gains.

The list below determines when you should start Clomid. Select from the list any steroids you've used in your cycle and whichever one has the latest starting point is the time to commence Clomid. For example, if Dianabol, Sustanon and Winstrol were cycled, the time for administering Clomid should be 3 weeks post cycle, as Sustanon remains active in the body for the longest period of time.
Steroid    Time after
last administration         Length of
Clomid Cycle
Anadrol50/Anapolan50:    8 - 12 hours         3 weeks
Deca durabolan:     3 weeks         4 weeks
Dianabol:     4 - 8 hours          3 weeks
Equipoise:     17 - 21 days         3 weeks
Finajet/Trenbolone:    3 days         3 weeks
Primabolan depot:    10 - 14 days         2 weeks
Sustanon:     3 weeks         3 weeks
Testosterone Cypionate:    2 weeks         3 weeks
Testosterone Enanthate/Testaviron:    2 weeks         3 weeks
Testosterone Propionate:    3 days         3 weeks
Testosterone Suspension:    4 - 8 hours         2-3 weeks
Winstrol    8 - 12 hours         2-3 weeks

How To Take Clomid
Clomid has a long half-life (possibly 5 days), so there is no need to split up doses throughout the day. If Sustanon has been used and Clomid is commenced 3 weeks after the last injection, I would estimate that androgen levels are low enough to start sending the correct signals. If androgen levels are still a little high, we need to start at a high enough amount that will work or help, even if androgen levels are still a little high. Try 300mg on day 1; then use 100mg for the next 10 days; followed by 50mg for 10 days.

Thursday, April 2, 2015

Insulin-like Growth Factor-1 (IGF-1)

IGF stands for insulin-like growth factor. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body; I will only mention the points that would be important for physical enhancement. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.

When IGF is active it behaves differently in different types of tissues. In muscle cells proteins and associated cell components are stimulated. Protein synthesis is increased along with amino acid absorption. As a source of energy, IGF mobilizes fat for use as energy in adipose tissue. In lean tissue,

IGF prevents insulin from transporting glucose across cell membranes. As a result the cells have to switch to burning off fat as a source of energy.

IGF also mimic's insulin in the human body. It makes muscles more sensitive to insulin's effects, so if you are a person that currently uses insulin you can lower your dosage by a decent margin to achieve the same effects, and as mentioned IGF will keep the insulin from making you fat.

Perhaps the most interesting and potent effect IGF has on the human body is its ability to cause hyperplasia, which is an actual splitting of cells. Hypertrophy is what occurs during weight training and steroid use, it is simply an increase in the size of muscle cells. See, after puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don't actually gain more. But, with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue, and through weight training and steroid usage you are able to mature these new cells, in other words make them grow and become stronger. So in a way IGF can actually change your genetic capabilities in terms of muscle tissue and cell count. IGF proliferates and differentiates the number of types of cells present. At a genetic level it has the potential to alter an individuals capacity to build superior muscle density and size.

There is a lot of talk about the similarity between IGF and growth hormone. The most often asked question is simply which is more effective. GH doesn't directly cause your muscles to grow, it works very indirectly by increasing protein synthesis capabilities, increasing the amount of insulin a person can use effectively, and increasing the amount of anabolic steroids a person can use effectively. GH also indirectly causes muscle growth by stimulating the release of IGF when it (the GH) is destroyed in the human body. So one way you could look at it as GH being a precursor to IGF. So to put it simple IGF is more effective at directly causing muscle growth and density increases. IGF is also much more cost effective.

IGF can also be effectively used by itself and gains will still be easily noticeable. With growth hormone you need to use high amounts of anabolics and often insulin to see any gains at all, this is not the case with IGF. IGF can be used by itself and is often used by bodybuilders who bridge between cycles, during this bridge is a good time to use IGF since it has no effect on natural testosterone production so it will therefore allow you to return to normal in terms of hormone levels. A stack of IGF, PGF2a, HCG, and clomid would be a good bridge stack and would allow your body to return to normal and still allow you to retain and make new gains.

IGF is a research drug, it hasn't been approved by the FDA for use as a pharmaceutical and it is currently being researched for nerve tissue repair, possible burn victims, and also as a possible aid in muscle wasting for AIDS patients. There are many different analogs of IGF available, instead of mentioning them all, I will simply mention the two most common and the most effective. Regular recombinant IGF is one of the two, it is also the more expensive and the least effective. Regular IGF only has a half-life of about 10-20 minutes in the human body and is quickly destroyed, it can be combined with certain binding proteins to extend the half-life, but it is not a very simple procedure and there is a more effective and less expensive version available. The most effective form of IGF is Long R3 IGF-1, it has been chemically altered and has had amino acid changes which cause it to avoid binding to proteins in the human body and allow it to have a much longer half life, around 20-30 hours. "Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substition of an Arg(R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide."

"Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF's."

It is also not as expensive since a media grade version is available which is sufficient for bodybuilding use. There is also a receptor grade available but it is VERY expensive and the only noticeable difference between the two would only be able to be noticed in a laboratory setting. The price on the black market for Long R3 IGF-1 can be seen anywhere from $300-$500 per milligram depending on the source, be wary of black market dealers of any IGF since it is a VERY difficult item to obtain. As mentioned IGF is a research product and is only available from a few laboratories in the world and is only available to research companies and biotechnology institutions. For the rest of this article when I say IGF I am now referring to Long R3 IGF-1 for simplicity sake.

Any form of IGF is ONLY supplied in a lyophilized form, which means a dry powder state. NEVER PURCHASE PRE-DILUTED LIQUID IGF!!!! There is no such product made anywhere in the world and even if there were real IGF ever present in the vial it would all be dead by the time you receive it. IGF is a very delicate peptide and must be diluted by yourself, where you have access to a refrigerator and freezer. There has also been a lot of talk by certain sources claiming to have IGF made by the Eli Lilly company, to clear things up Lilly is a pharmaceutical company and as stated IGF is a research drug and has not yet been approved, Lilly does not and never has manufactured research drugs for retail sale. 

The diluents you will need for the IGF are a weak concentration of hydrochloric acid and a sterile buffer sterile water or bacteriostatic water) the procedure for diluting the IGF is not very difficult, the diluents can be obtained from most local chemical suppliers and a good source of IGF would also be able to supply the necessary diluents.

The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage. The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day and so on. The dosage issue mainly revolves around how much money you have to spend, plenty of people use the minimum dosage of 20mcg/day and are happy with the results, and in fact several top bodybuilders use the 20mcg/day dosage and are pleased with the results. IGF is most effective when administered subcutaneous and injected once or twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training.

Another frequently asked question of IGF refers to the real world results, in terms of pure weight gain don't expect to gain 5 lbs. a week like you may off of anadrol or a similar steroid. The only weight you will gain from IGF use is pure lean muscle tissue, with steroids most of the weight gained is water weight. With an effective dosage you can expect to gain 1-2 lbs of new lean muscle tissue every 2-3 weeks and these effects can be increased with the use of testosterone, anabolic steroids, and insulin use. Increased vascularity is also very common, people report seeing veins appear where they never have before. And yet another effect reported is the ability to stay lean while bulking with heavy dosages of steroids and TONS of food while on an IGF cycle, this is perhaps the most pleasing effect. Increased pumps are also noticeable almost immediately, the pumps can almost become painful, pumps are even noticeable when doing cardio.

Overall, IGF is a very exciting drug due to its ability to alter ones genetic capabilities. If you can find a trustworthy source and you use it correctly it can be a VERY useful tool in your bodybuilding drug arsenal.

Thursday, March 26, 2015

Test E, Deca and DBol: The Bulking Stack

The purpose of this article is to educate the amateur bodybuilder on the correct set up of a powerful traditional bulking cycle; Test e, Deca, and Dbol. The use of Deca and Dbol has been long hailed as the mighty bulking cycle. Traditionally used as an off season cycle, the stack will do a wonderful job of adding muscle mass and letting the user come in at a heavier weight when reaching their goal body fat when cutting.

TESTOSTERONE ENANTHATE:

I have said it a million times before and I will say it again, testosterone is king. It is the foundation in which all cycles are built upon. Running any compound without the use of testosterone will leave you with hormone levels that are similar to a females. Testosterone Enanthate is a slower acting ester. With a 7 to 10 day half-life, it requires a less frequent dosing schedule to reach and maintain stable blood levels making it the better choice for beginner steroid users who may not be too fond of needles and do not want to do every day or every other day injections. Properly used, the injection schedule should be every 3.5 days on Monday and Thursday of the week. Dosages for testosterone enanthate range from a minimum of 400mg a week to 800mg a week for the average steroid user and cycles should be a minimum of 10 weeks due to the amount of time it takes to reach peak levels. More advanced users have been known to go over 1000mg a week, but one should be aware that it takes a lot of cycle experience to get to those levels. Longer estered testosterones like testosterone enanthate are known to cause more estrogen/aromatization side effects due to higher peak values over the course of the cycle. Proper AI/SERM precautions should be taken.

DECA DURABOLIN:

Deca has been the go to compound for bulking in bodybuilding amongst steroid users for years. Deca is a 19-nor compound. Its made from the same cloth as trenbolone. Consequently, it also shares many of the same issues as Tren. Being a 19-nor, deca is liver toxic. It also does not aromatize very well, but will cause a rise in progestin levels. Due to its ability to rise progestin levels, deca is known for causing libido issues or “deca dick.” Proper progestin/anti-estrogen drugs should be used to make sure you keep you from experiencing libido issues. It also will shut down natural testotsterone almost immediately with the first dose. Deca has as strong affinity to the androgen receptor and does great as an anabolic; it will raise both nitrogen retention and igf levels. Water retention does become an issue on deca, but the proper progestin drugs should keep it at bay. Deca is also known to help joint issues by storing water in the connective tissues and inproving collagen synthesis/mineral content. Some use the drug in low dosages such therapeutic effects. The recommended proper dosage for Deca is between 400-600mg a week. Though the ester connected to deca has a longer half life, its safe to inject deca on the same schedule as test e and c. In theory, deca can be injected once a week, but twice a week is the gold standard. Due to the highly suppressive nature of deca, its recommended that hcg be ran with the cycle.

DIANABOL:

Dbol is traditionally found in pill form. Like winstrol, Dbol is a 17aa oral steroid. 17aa orals are made the way they are to survive the first pass at the liver. Unfortunately, this makes dbol highly liver toxic (almost as toxic as winny). Dbol will also cause hypertension (a raise in blood pressure) so proper monitoring of your blood pressure should be maintained. Dbol is not the best at binding with the androgen receptor and most its effects are secondary. Dbol will suppress natural testosterone production. Many who are new to steroid use will try to do a Dbol only cycle. When dbol suppresses your natural production your levels start looking more like a females. Therefore, it should always be ran in a cycle with testosterone as a base. Dbol is said to be as strong as anadrol, though most will not see the same effects due to unequal dosages. Dbol is known as a kick start compound in cycles. Its ability to add weight comes on quickly and many people use it in the first 6 weeks of their cycle. Dosages range from 20-100mg a day, though an amateur user should stick to under 50mg to start.

The Cycle:

OK, lets set up a cycle for a first time user of these compounds combined. Keep in mind this isn’t a beginners cycle and stacking multiple compounds that you haven’t used in the same cycle may cause side effect and leave you wondering what the source of the issue was.

    Testosterone Enanthate 300mg twice a week   Week 1-12steroid muscle stack
    Deca 200mg twice a week Week 1-12
    Dbol 30-50mg a day Week 1-6
    HCG 500iu a week (250iu twice a week) Week 1-12

Post Cycle Therapy

    Clomid 100/50/50/50
    Nolva 40/40/20/20

Thursday, February 19, 2015

Sleepiness and Clenbuterol

Clenbuterol is a weight loss method that is being used by thousands.

Though it is a steroid like substance it is not a steroid. Part of a drug group known as “beta-2-agonists (a group of drugs to treat pulmonary disorders).

They act much like stimulants in as much as they produce rapid heart rate and blood pressure increase).Its primary development was for horses with equine asthma disorder. The horses that have used these drugs cannot be slaughtered for food after use.

Bodybuilders, particularly females have become especially attracted to Clenbuterol due to its lack of production of androgenic side effects (such as voice deepening and hairiness) as well as its quick weight loss and muscle defining abilities.

Clenbuterol side effects:

This list of side effects is considered short-term side effects. Clenbuterol has not been studied enough for complete long-term effects in humans.

Muscle cramps

Hypertension

Tremors

Insomnia

Anxiety

Dry mouth

Breathing difficulties

Headaches

Nervousness

Long term effects as known:

    As demonstrated in animals, heart muscle enlargement is a potential long-term effect.
    In rodents increases the risk of aortic enlargement after exercise.
    Rodent testing has demonstrated that those with pre-existing heart conditions are more apt to develop very quickly left side cardiac atrophy.
    Increased bone fractures due to the muscle mass and muscle fragility.

Overdose symptoms:

Tachycardia (increase of heart rate)

Hypokalemia (decrease in potassium)

Vertigo

Stroke

Headaches

Tremors

These effects will last as long as the Clenbuterol is in your system. Not everyone has side effects from Clenbuterol including insomnia. In many instances the side effects may occur due to not taking Clenbuterol correctly.

     High dosage for first time use – in an attempt to gain more rapid results, people may take more than should be taken. The recommended dose is 40 mcg, regardless of being a male or female.
    Stacking – Again in trying to achieve rapid results users may stack with other stimulants, this is not recommended particularly with your first cycle.
    Nutrition – Good nutrition is always advised regardless of what weight loss method you select. Start your day with a glass of water and eat small portions of food throughout the day.
    Not enough water – Without at the least 2.5 liters per day of water than you will suffer from lack of energy. This is where the sleepiness will enter the scenario. Due to the temperature rise in your body, you will sweat more and this requires more energy and water.

If you do not have any side effects from Clen this means that your body can tolerate it. This is a good thing. Avoid making the mistakes as mentioned above to help prevent or lessen any side effects.

There is one side effect that essentially cannot be explained and that is the one of rapid weight increase. It has been proven that long-term use will cause Clen to lose its capacity to produce your desired effect. Instead what you will receive within a short period of time (3 -4 weeks) rapid weight gain. The reason for this is still unknown.

It has been suggested that Clenbuterol has found its way into Hollywood and is responsible for the extraordinary amount of size 4 stars. Whether this is true or not may be seen in the future indicators of side effects or overdoses caused by Clen.


There is still much to be learned about Clenbuterol. There are still many countries that do not allow it for human consumption. However, this is a substance that is easy to obtain through the Internet, regardless of where you may live.

Tuesday, February 10, 2015

Get rid of gyno with GP Letrozole

GP Letrozole and your sex drive:
Letrozole will suppress your sex drive. This is another reason why it is so important to act on preventing gyno as soon as possible. Since we all know that Test should be run in every cycle this will cancel out the effect of sex drive suppression.

Running GP Letrozole to prevent gyno:
If you decide to run estrogen protection while on cycle, you can run either a Selective estrogen receptor modulator or an Aromatise Inhibitor. GP Letrozole will be the most powerful Aromatise Inhibitor you can use, it will inhibit 98+% of estrogen using a dose as low as .25mg and even lower. This is why is suggested do not use a dose higher than .50mg while on cycle just trying to prevent estrogen related side effects.

You will want to start running the GP Letrozole approximately 2 weeks before you begin your cycle to allow it to fully stabilize in your blood. It's popular argument that letro takes up to 60 days to stabilize. To be safe - start it before your cycle as stated above.

If you do decide to run GP Letrozole there is absolutely no need to run another Aromatise Inhibitor or Selective estrogen receptor modulator. Do not make the mistake of thinking more is better. Think of it this way; if letro is preventing the conversion of androgens to estrogen than there is no estrogen, what would the purpose of a Selective estrogen receptor modulator be when there is no estrogen to bind to the receptors? Nolva will only take away from the effectiveness of letro.

Do not listen to anyone who tells you to bump up your nolvadex to 60+mg ED if you get gyno. Nolvadex will do nothing to reverse your gyno…let me make that clear IT WILL DO NOTHING FOR GYNO. If you are running nolva as your anti-e and start to develop gyno than sure you can bump the dosage a small amount to try to prevent it from progressing further, but letrozole must begin ASAP.

It is very important that you begin taking GP Letrozole immediately, the longer your wait the more risk you take in not being able to reverse it.

How do I know if I have gyno?
If you have developed gyno you will have a lump behind your nipple. It will be fairly hard, and it will be tender to touch.

Running letro to reverse gyno:
There are three different scenarios which people could fit into. Remember regardless of what scenario you are in it is important that you begin taking the letro ASAP.

1. Already using an anti-e aside from GP Letrozole.
2. Already using GP Letrozole @ a dose of .25mg or .50mg ED.
3. Not running any estrogen protection.

1.
Day 1: .25mg GP Letrozole + anti-e*
Day 2: .50mg GP Letrozole
Day 3: 1.0mg GP Letrozole
Day 4: 1.5mg GP Letrozole
Day 5: 2.0mg GP Letrozole
Day 6: 2.5mg GP Letrozole **

2.
Day 1: .50mg GP Letrozole
Day 2: 1.0mg GP Letrozole
Day 3: 1.5mg GP Letrozole
Day 4: 2.0mg GP Letrozole
Day 5: 2.5mg GP Letrozole **

3.
Day 1: .50mg GP Letrozole
Day 2: 1.0mg GP Letrozole
Day 3: 1.5mg GP Letrozole
Day 4: 2.0mg GP Letrozole
Day 5: 2.5mg GP Letrozole **

*Regardless of the anti-e you are using it is important to still use it for the first day you begin GP Letrozole as the GP Letrozole will not have taken any effect and you by no means want your body to be without any protection when gyno is already prevalent.

** You will remain at this dose until gyno symptoms subside. Once you believe your gyno is gone it is important to stay at this dose for another 4-7 days to ensure all traces are gone. People with a bf% over 15 stay on for a week as it may be harder to judge completely whether the lump is completely gone. Once this period is over it will be important to taper letro down slowly rather than coming off it completely. Regardless of which manner you tapered up your dose you will all taper down in the same fashion.

Day 1: 2.0mg
Day 2: 1.5mg
Day 3: 1.0mg
Day 4: .50mg***
Day 5: .25mg
***You can remain at this dose or go down further to .25mg. It is really up to you at this point. They are both very common maintenance doses as an anti-e while on cycle.

Letro and the estrogen rebound:
With your estrogen being completely inhibited there is a definite estrogen rebound as your body tries to re-stabilize the testosterone:estrogen balance. We can prevent this rebound effect by supplementing further with another Aromatise Inhibitor or Selective estrogen receptor modulator. When you are coming to the end of your cycle you will more than likely be using GP Nolva in your PCT so just make sure that you begin taking nolva the last day you are going to take your letro and then continue on as you would with regular PCT.