FitnessDose

Thursday, April 24, 2014

Testosterone Recovery After Deca Durabolin

When it comes to negative side effects associated with anabolic steroids, some are far worse than others. Deca Durabolin, perhaps one of the most popular anabolic steroids ever used, and still widely used, is known as mild compared to other commonly used androgens. The parent hormone is Nandrolone and is found in both Deca Durabolin and NPP (Nandrolone Phenylpropionate) and it doesn’t seem to come across as a harsh hormone to use from years of medical data and reports from steroid users. Acne, hair loss, aggression, increases in blood pressure and drastic changes in lipids, kidney function and liver values are not usually attributed to Deca Durabolin use. But there is one side effect that it exerts significantly, and that’s testosterone suppression or inhibition.

When an athlete or bodybuilder uses anabolic steroids, endogenous testosterone function will decrease from use. Different compounds effect testosterone production to varying degrees, but Nandrolone, or Deca-Durabolin is perhaps the most powerful of all commonly used anabolic steroids with Trenbolone. “Deca dick” is a known side effect or slang term given to erectile dysfunction, which has affected a large degree of steroid users and questions spear on large steroid forums daily. Due to the speed of which Deca can suppress natural testosterone production recovery post cycle can be harder than most steroid cycles not containing Deca Durabolin.

Today we’re going to look at a study that looked at 21 men who had been taking Nandrolone Decanoate (Deca Durabolin) and their recovery efforts after coming off of anabolic steroids. The study was conducted in Sweden at the Karolinska Institutet. The researchers found the subjects through an anti-doping hotline setup to help steroid users in Sweden. They state that the participants had “a genuine will to stop using anabolic steroids.”

Deca Durabolin is Nandrolone with the Deconoate ester attached allowing it to stay active for 21 days; however, its metabolites are present far longer in the body. 19-norandrosterone and 19-noreticholanolone appear to remain active for months after use, this may shed light on why its so hard to recover natural testosterone levels. Deca is also known to last in an athletes blood for over 12-16 months which makes it a very bad choice for athletes or bodybuilders in tested sports.

Importantly, the Swedes also tested levels of leutinizing hormone (LH) and follicile stimulating hormone (FSH). LH and FSH are responsible for stimulating the testes (leydig cells) to secrete testosterone. In the figure above you’ll see that LH and FSH were still rising over 12 months after Deca-Durabolin cessation, confirming reports its one of the hardest anabolic steroids to recover from.

Limitations are that this study did not state a post cycle therapy (PCT) was used by any of the steroid users. This is where anti-estrogen use helps the body reover from a steroid cycle. We recommend all steroid users conduct a full PCT after using anabolic steroids whilst combining them with an aromatase inhibitor and also human chorionic gonadotropin (HCG) to help maintain testicular size and function. HCG is suggested at 250-500ius per week or every 3-4 days. If side effects occur, or testosterone recovery isn’t possible or problematic, seek the guidance of a physician or endocrinologist.

Tuesday, April 15, 2014

HCG Human Chorionic Gonadotropin

Human Chorionic Gonadotropin (HCG) is what is known as a protein hormone (or a peptide hormone) that is naturally and endogenously  produced by the female human body by the syncytiotrophoblast cells in the placenta. In females, HCG plays a very important role in stimulating the release of Progesterone, which is a hormone vitally essential for pregnancy. HCG that is bottled for human use is not synthesized in creation, but is instead obtained from humans. Specifically, it is found in very high concentrations in pregnant females as previously stated. HCG is in fact what is used as the number one primary indication of pregnancy in females, as it is only present in very, very high quantities in females during pregnancy. HCG is what the home pregnancy tests detect in urine, and if present in significant quantities, the home pregnancy tests will turn blue. In women who are pregnant, HCG increases in the body rise very rapidly, and can be detected within 7 days of increased secretion in the body. At this time period, however, HCG levels are only beginning to rise, and blood plasma levels of HCG do not actually peak until approximately 2 – 3 months into pregnancy. Following this 2 – 3 month period, HCG levels then begin to decline.

HCG itself could technically be considered synthetic LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone), but the truth is that HCG is indeed a different hormone, but in men it will mimic the actions of LH and FSH identically. LH and FSH are gonadotropins manufactured and secreted by the pituitary gland, and these two hormones in men signal the Leydig cells in the testes to begin or increase the manufacture of Testosterone. The term ‘gonadotropin’ refers to any compound or hormone that stimulates the gonadal organs (testes in men, ovaries in females). In females, LH and FSH trigger ovulation (the manufacture of eggs in the ovaries). HCG, because it is essentially a mimic of LH and FSH in terms of its physiological activity, is administered medically to females that suffer from infertility (perhaps because they do not endogenously manufacture sufficient levels of gonadotropins as it is or for other reasons). Within medicine, HCG is also administered to males for the treatment of hypogonadism (deficient androgen production). It is also used medically for the treatment of pubertal delay in adolescent males, as well as prepubertal cryptorchidism, which is a condition in which an individual’s testicles have improperly descended (either during or after puberty). Among the anabolic steroid using bodybuilders and athletes, HCG has been utilized for a long time for its ability to restore endogenous Testosterone production following the termination of an anabolic steroid cycle. This is a period in which hormonal restoration is imperative, and HCG is normally inserted into a multi-compound protocol of approximately 4 – 6 weeks after an anabolic steroid cycle has ended, and this is known as PCT (Post Cycle Therapy).

Despite what rumors one may hear, HCG is ineffective for fat loss, and holds no capabilities in stimulating the thyroid gland to manufacture more thyroid hormone. This must be made especially clear due to the fact that for a long time, HCG was utilized wrongfully and mistakenly to treat obesity, with the origins of this practice coming from a wrongfully interpreted study in 1954. This study claimed that test subjects had lost significant amounts of body fat following the use of HCG while on a severely low caloric deficit (500 calories daily). Many interpreted the study wrongfully, and focused solely on the fact that HCG was utilized without any thought for the caloric deficit used in the subjects. More than 30 years later, the whole study and HCG-centered medical treatments for obesity were reviewed, and the approved use for the treatment of obesity was eliminated.

Little did people know that the severe caloric restriction caused individuals to lose important lean tissue mass (muscle) as well as important organ tissue in order to preserve itself, and that this result of severe caloric deficits were worse on the body than obesity. Eventually the FDA in 1974 had even issued a statement on all pamphlets that were packaged with HCG that made it very clear that the use of HCG for fat loss is ineffective and should not be used as such.

Today HCG is still widely utilized in medicine, and is widely available on all markets internationally under various major brand names (Pregnyl by Organon, Profasi by Serono and Novarel by Ferring, as well as many others) including an abundance of generic HCG as well.  HCG is a non-controlled substance in almost all countries in the world, including in the United States (although it is still only obtainable by prescription there, it is not a controlled substance). Because of its immense popularity, overabundance on the market, and ease of manufacture, counterfeits and fakes are not an issue.

Chemical Characteristics of HCG
Human Chorionic Gonadotropin (HCG) is a protein (or peptide) hormone, but it is more specifically referred to as an oligosaccharide glycoprotein (a protein molecule that contains one or more carbohydrates/sugar molecules affixed to it as well). Its protein structure consists of an amino acid chain of 244 amino acids, with a sub-unit of 92 amino acids on it that is 100% identical to LH and FSH. It is this subsection of the HCG molecule that enables it to mimic the action of LH and FSH 100% identically on the same receptors in the cells that LH and FSH activate.